Publications
     
Selected Congenia publications related to the mPTP/p66 platform are given below.

P66Shc signals to age.
Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A, Pelicci P, Giorgio M. Aging (Albany NY). 2009 Jun 5;1(6):503-10. Review.

Blood orange juice inhibits fat accumulation in mice.
Titta L, Trinei M, Stendardo M, Berniakovich I, Petroni K, Tonelli C, Riso P, Porrini M, Minucci S, Pelicci PG, Rapisarda P, Reforgiato Recupero G, Giorgio M. Int J Obes (Lond). 2010 Mar;34(3):578-88.

p66Shc-generated oxidative signal promotes fat accumulation.
Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M. J Biol Chem. 2008 Dec 5;283(49):34283-93.

Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
Giorgio M, Trinei M, Migliaccio E, Pelicci PG. Nat Rev Mol Cell Biol. 2007 Sep;8(9):722-8. Review.

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc.
Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R. Science. 2007 Feb 2;315(5812):659-63.

Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.
Orsini F, Moroni M, Contursi C, Yano M, Pelicci P, Giorgio M, Migliaccio E. Biol Chem. 2006 Oct-Nov;387(10-11):1405-10.

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis.
Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, Pelliccia G, Luzi L, Minucci S, Marcaccio M, Pinton P, Rizzuto R, Bernardi P, Paolucci F, Pelicci PG. Cell. 2005 Jul 29;122(2):221-33.